At the present, in the United States and worldwide, certain specific medical enzymes are used legally as ethical and effective systematic treatment for a number of conditions. They are approved by the FDA for the use in the treatment of specific diseases where there is general agreement about their effectiveness. These condition and illness include cardiovascular disorders, gastrointestinal conditions and removal of toxic substances from the blood. In the United States, the 1993 physicians desk reference (PDR) list around 40 enzyme preparations approved by the FDA for use in the country. These include for the preparations for the oral, injectable (intravenous or intramuscular use) or topical administration. At present the most publicized and probably most important therapeutic use of the enzyme in U.S, is in the treatment of the various diseases. Include here are heart attacks (acute myocardial infections), blood clots of the legs and the other areas (deep venous thrombosis), and blood clots in the lungs (extensive pulmonary embolism) they are also use by the such related support service as for clogged arteriovenous canulae and for reperfusion. The enzyme used primarily for these purposes are tissue plasminogen activator (TPA), streptokinase and urokinase. The enzyme can be administrated intracorporeally (intravascular), or extracorporeally. The latter include various modalities of dialysis and pheresis.